Granulated Tissue Burned With Nitrate and Week Later Bleeding Again

Generic Name: silver nitrate

Drug Class: Topical Antimicrobials

What is silver nitrate, and what is it used for?

Silver nitrate is a chemical compound of silver cation and nitrate anion. Ions are charged particles, cations are positively charged and anions are negatively charged. Argent nitrate solution is used topically equally an anti-infective agent to:

  • Cauterize infected wound tissue, a procedure that destroys the infected cells on wounds
  • Remove warts and backlog granulation tissue, a type of tissue with new blood vessels that forms in wound repair stage

Silver nitrate can protect wounds from bacterial infection and inhibit the growth of both gram-positive and gram-negative bacteria, the two main classifications of bacteria based on their structure. Silverish ions react with the bacterial proteins and alter the structure of the bacterial jail cell wall and membrane, killing them in the process. Silverish ions coagulate the proteins in the wound tissue forming a layer of dead tissue (eschar), which stops haemorrhage, facilitates wound closure and healing, and also prevents the penetration of silver nitrate into deeper tissue.

Silver nitrate is available equally a prescription medication but is non canonical past the FDA. Uses of silver nitrate include:

  • Cauterization of infected tissue effectually skin wounds
  • Removal of warts, skin tags, and granulation tissue
  • Cauterization of wounds in mucous membranes including:
    • Pocket-sized ulcers in the mouth
    • Infected tonsils
    • Vaginal or cervical ulcerations and erosions
    • Rectal fissures and fistulae
  • Superior limbic keratoconjunctivitis, a condition that causes chronic inflammation in the area above the cornea in the eye

Warnings

  • Do non use in patients with known hypersensitivity to silver nitrate
  • Silver nitrate is corrosive and can cause chemical burns; wear chemical-resistant gloves and other appropriate personal protective equipment while applying and take care to restrict application to only the affected area
  • Practise non employ on broken peel, open wounds or cuts
  • Silver nitrate can irritate the skin and mucous membrane; avoid prolonged contact with skin, particularly on thin delicate pare and babies' skin
  • Silver nitrate can stain the skin black, which mostly disappears gradually within two weeks

What are the side furnishings of silver nitrate?

Mutual side effects of silverish nitrate include:

  • Discoloration of skin
  • Local irritation and burning on the awarding site
  • Methemoglobinemia, a condition with excessive blood level of methemoglobin, a form of hemoglobin that doesn't transfer oxygen effectively to the tissues

This is not a complete list of all side furnishings or adverse reactions that may occur from the use of this drug.

Phone call your medico for medical advice well-nigh serious side effects or agin reactions. You may also report side effects or health problems to the FDA at i-800-FDA-1088.

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What are the dosages of silvery nitrate?

Topical solution

  • 0.five%
  • 10%
  • 25%
  • fifty%

Applicator sticks

  • 75%

Adult and Pediatric:

Antiseptic Wound Cauterization

  • Sticks: Employ to mucous membranes and other moist peel surfaces simply on the surface area to be treated
  • Topical solution: Apply a cotton applicator dipped in solution/ointment on the affected expanse ii-3 times per week for 2-3 weeks

Only adult:

Superior Limbic Keratoconjunctivitis (Off-label)

  • Apply 0.5-1% solution to anesthetized upper tarsus (inner eyelid area to a higher place the lid margin), allow it to fall dorsum into place over the affected palpebral conjunctiva
  • Irrigate with sterile saline after 1 minute
  • It may be repeated afterwards 4-vi weeks

Overdose

  • Excess application of silver nitrate can be neutralized by treating the area with saline solution and rinsing it with sterile water.

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What drugs interact with silver nitrate?

Inform your dr. of all medications you are currently taking, who tin advise you on any possible drug interactions. Never begin taking, suddenly discontinue, or alter the dosage of any medication without your dr.'southward recommendation.

  • Silver nitrate has no known severe interactions with other drugs.
  • Silver nitrate has no known serious interactions with other drugs.
  • Moderate interactions of silver nitrate include:
    • collagenase
    • papain
    • sodium sulfacetamide
    • sulfacetamide topical
    • trypsin
  • Argent nitrate has no known minor interactions with other drugs.

The drug interactions listed above are not all of the possible interactions or adverse effects. For more information on drug interactions, visit the RxList Drug Interaction Checker.

It is of import to e'er tell your doctor, chemist, or health care provider of all prescription and over-the-counter medications y'all use, likewise as the dosage for each, and continue a list of the data. Cheque with your doctor or health care provider if you have any questions nigh the medication.

Pregnancy and breastfeeding

  • There are no well-controlled studies on silver nitrate utilize in pregnant women. Employ if potential benefits to the female parent outweigh possible risks to the fetus.
  • There are no studies on use of silver nitrate in nursing mothers; avoid use.

What else should I know about silver nitrate?

  • Silver nitrate is to be used just topically; do not take orally, it tin cause severe gastroenteritis that may be fatal; in case of adventitious ingestion, seek medical help immediately or contact Poison Command
  • Do non utilise applicator sticks on eye and topical solution on mucous membranes
  • Use extreme intendance in handling silver nitrate; it is a corrosive substance
  • Keep silver nitrate safely out of achieve of children

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Summary

Silver nitrate solution is used topically every bit an anti-infective amanuensis to cauterize infected wound tissue, and remove warts and backlog granulation tissue. Common side effects of silverish nitrate include discoloration of pare, local irritation and burning on the application site, and methemoglobinemia. There are no well-controlled studies on silver nitrate use in meaning women. Use if potential benefits to the mother outweigh possible risks to the fetus. There are no studies on use of silver nitrate in nursing mothers; avert use.

Treatment & Diagnosis

Prevention & Wellness

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Medically Reviewed on 5/2/2022

References

https://www.rxlist.com/consumer_silver_nitrate/drugs-condition.htm

https://reference.medscape.com/drug/silver-nitrate-343589#0

https://www.uptodate.com/contents/silver-nitrate-drug-information

https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/silver-nitrate

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Source: https://www.medicinenet.com/silver_nitrate/article.htm

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